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PUBLICATIONS
Charidemou E, et al. Hyperacetylated histone H4 is a source of carbon contributing to lipid synthesis. EMBO Journal doi: 0.1038/s44318-024-00053-0 (2024)
Constantinou M, et al. Cellular effects of NAT-mediated histone N-terminal acetylation Journal of Cell Science doi: 10.1242/jcs.260801 (2023)
Charidemou E, et al. Histone methylation in pre-cancerous liver diseases and hepatocellular carcinoma: recent overview. Clinical and Translational Oncology doi: 10.1007/s12094-023-03078-9. (2023)
Kukhtevich, I. et al. Quantitative RNA imaging in single live cells reveals age-dependent asymmetric inheritance. Cell Reports doi: 10.1016/j.celrep.2022.111656. (2022)
Charidemou, E. et al. Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis
BMC Biology, https://doi.org/10.1186/s12915-021-01225-8 , (2022)
Demetriadou, C. et al. Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance Oncogene, (2021)
Koufaris, C. Kirmizis, A. Identification of NAA40 as a Potential Prognostic Marker for Aggressive Liver Cancer Subtypes. Frontiers in Oncology doi: 10.3389/fonc.2021.691950 (2021)
Publications: Publications
Koufaris, C. Kirmizis, A. N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours. Cancers 12(9):E2631 (2020)
Bheda, P. Kirmizis, A. Schneider, R. The past determines the future: sugar source history and transcriptional memory. Curr Genet. doi: 10.1007/s00294-020-01094-8. (2020)
Demetriadou, C. Koufaris, C. Kirmizis, A. Histone N-alpha terminal modifications: genome regulation at the tip of the tail. Epigenetics Chromatin. 13(1):29 (2020)
Kyriakou, D. Constantinou, M. Kirmizis, A. Synthetic dosage lethal (SDL) interaction data of Hmt1 arginine methyltransferase. Data Brief. 31:105885 (2020).
Bheda P, Aguilar-Gómez D, Becker NB, Becker J, Stavrou E, Kukhtevich I, Höfer T, Maerkl S, Charvin G, Marr C, Kirmizis A*, Schneider R*. Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory. Mol Cell. 78(5):915-925.e7 (2020)
*co-corresponding authors
Demetriadou, C. et al. NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression. Cell Death Disease, 10(3):236 (2019).
Molina-Serrano, D., Kyriakou, D., Kirmizis, A. Histone modifications as an intersection between diet and longevity. Frontiers in Genetics, 10:192 (2019).
Demetriadou, C & Kirmizis, A. Histone Acetyltransferases in Cancer: Guardians or Hazards? Critical Reviews in Oncogenesis 22:195-218 (2017)
Molina-Serrano, D & Kirmizis, A. Calorie restriction breaks an epigenetic barrier to longevity. Cell Cycle 20:1-2 (2017).
Molina-Serrano, D. et al. Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity. EMBO Rep 17(12):1829-1843 (2016).
Kyriakou, D. et al. Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae. BMC Biology 14(1):106 (2016).
Pavlou, D. & Kirmizis, A. Depletion of Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway. Apoptosis 21:298-311 (2016).
Schiza, V. et al. N-alpha-terminal acetylation of histone H4 regulates arginine methylation and ribosomal DNA silencing. PLoS Genetics 9(9):e1003805 (2013).
Molina-Serrano, D. et al.Cross-talk among epigenetic modifications: lessons from histone arginine methylation. Biochem Soc Trans 41(3):751-759 (2013).
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Kirmizis, A. et al. Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2. Nature Struct Mol Biol 16, 449-451 (2009).
Santos-Rosa, H., Kirmizis, A. et al. Histone H3 tail clipping regulates gene expression. Nature Struct Mol Biol 16, 17-22 (2009).
Kirmizis, A. et al. Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature 449, 928-32 (2007).
Kirmizis, A. and Farnham, P.J. Genomic approaches that aid in the identification of transcription factor target genes. Exp Biol Med 229,705-721 (2004).
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Kirmizis, A. et al. Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes & Development 18, 1592-1605 (2004).
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Kirmizis, A. et al. Identification of the polycomb group protein SUZ12 as a potential molecular target for human cancer therapy. Mol Cancer Ther 2, 113-121 (2003).
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